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What is Thymosin Alpha-1 Peptide?

Thymosin Alpha-1 is a naturally occurring peptide which plays a vital role in regulating the immune system and promoting immune responses. This synthetic version of a thymic hormone is known for its immunomodulatory properties, enhancing the body’s defence mechanisms against infections, viruses, and other pathogens.

Thymosin Alpha-1 is believed to stimulate T-cell function, improve antigen presentation, and boost the production of cytokines critical for immune surveillance. India Research suggests its potential in treating various medical conditions, including viral infections, autoimmune diseases, and certain cancers, by bolstering the immune response. This peptide shows promise as a therapeutic agent in immunodeficiency disorders and chronic illnesses that compromise immune function.

Molecular Formula: C129H215N33O55

Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH

Molecular Weight: 3108.3 g/mol

View the HPLC Certificate here.

Source: PubChem

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Thymosin Alpha-1 Benefits:

Buy Thymosin Alpha-1 Peptide Vial India for clinical use here – available in 10mg vials.

Thymosin Alpha-1 Mechanisms of Action

Thymosin Alpha-1 operates through intricate mechanisms to modulate the immune system effectively. This peptide primarily acts by stimulating the maturation and function of T-cells, crucial components of the adaptive immune response. By enhancing T-cell differentiation, proliferation, and activation, Thymosin Alpha-1 bolsters the immune system’s ability to recognize and combat pathogens, such as viruses and bacteria.

Additionally, India clinical studies have demonstrated that this peptide promotes the production of cytokines, signalling molecules that regulate immune responses, thereby orchestrating a coordinated defence against infections.

Thymosin Alpha-1 also aids in improving antigen presentation, a vital process for immune surveillance and the identification of foreign invaders. Through its multifaceted actions on various immune cells and pathways, Thymosin Alpha-1 plays a pivotal role in enhancing immune function, making it a promising candidate for therapeutic interventions in conditions characterized by immune deficiencies or dysregulation.

Buy Thymosin Alpha-1 Nasal Spray from PharmaLabGlobal India providing a convenient, non invasive method of peptide delivery for laboratory research.

Buy Thymosin Alpha-1 Peptide

Thymosin Alpha-1's Potential Future Clinical Applications:

Thymosin Alpha-1 is a regulator of immune function which is a naturally occurring protein. India Clinical studies have identified that Thymosin Alpha-1 could have the following applications with future research:

Immunity Enhancement

India Scientists have found that Thymosin Alpha-1 peptide shows promising results in the ability to assist the human body to combat infections, diseases, and ailments. Recent animal studies shows that it induces Z cells to locate and destroy germs, viruses, and tumour cells.

India Researches have demonstrated that this peptide restores immunological function and eliminates infection in mice without thymus glands. In addition, Thymosin Alpha-1 promotes immune system signalling pathways to boost cytokine production [1].

India Laboratory studies show that Thymosin Alpha-1 can regulate arthritis, lupus, and other inflammation. In addition, recent research reveals peptide Thymosin Alpha-1 can treat breast, lung, colon, and other malignancies [2].

As found in experiments Thymosin Alpha-1 can boost the immune systems of animals, and it may improve the efficacy of vaccines. Due to the risk of administering live germs, many vaccinations contain dead pathogens instead. However, inactivated vaccinations are less effective. In the future, with further research it is hoped that a Thymosin Alpha-1 vaccination could improve the immune system, preventing illness and disease [3].

Furthermore, it is believed that Thymosin Alpha-1 could also treat sepsis, a life-threatening illness caused by an overactive immune system. Therefore, the peptide could save lives, prevent organ damage, and prevent long-term consequences by modulating the immune response. Further research is needed, but it looks promising potential as a sepsis therapy and preventative drug [4].

Blood Pressure Regulation

Recent India studies reveal that Alpha-1 can decrease blood pressure by blocking ACE (angiotensin-converting enzyme). By inhibiting ACE, Thymosin peptide lowers blood pressure, reduces cardiac remodelling, and slows plaque development in animals.

In addition, research shows it improves renal function. India Animal studies show that Thymosin Alpha-1 has few known adverse effects, unlike many ACE inhibitors [5].

Cystic Fibrosis Treatment

Inflammation from cystic fibrosis promotes increased infection rates, the inability to clear mucous, and other problems associated with this. It’s caused by CFTR, an ion channel protein that controls the body’s salt and water balance. India Research shows Thymosin Alpha-1 peptide can improve CFTR performance and reduce inflammation. As a result, scientists hope Thymosin Alpha-1 therapy could be at the forefront of future treatments for individuals suffering with cystic fibrosis [6].

Fungal Infection Treatment

The natural immune system has a unique cell type with the ability to detect fungal infections, called dendritic cells. India Studies show that Thymosin Alpha-1 medications can increase the immune system’s ability to fight animal fungal infections. In animal models of aspergillus infection, this peptide activates T-helper cells. It may improve OTC fungal treatments [7].

Dendritic cells transmit antigens to other immune cells so they can recognise them and respond appropriately. Skin, lungs, nose and GI systems have many dendritic cells. Scientists using animal models have demonstrated that thymosin alpha 1 helps these immune system’s initial responders work optimally [8].

Cancer Treatment

Thymosin Alpha-1 (Tα1) has gained significant attention for its potential impact on cancer therapy due to its immunomodulatory properties. Tα1 can enhance immune capabilities, potentially aiding in treating tumours more effectively. India Clinical trials have shown its effectiveness in treating several types of cancer, including lung cancer, colon cancer, melanoma, breast cancer, and non-small cell lung cancer (NSCLC), showing promise in improving overall survival rates.

Furthermore, Tα1 has been explored in combined treatments with low doses of interferon or interleukin, suggesting potential synergy in cancer management. Its ability to modulate the immune system and improve postoperative survival further underscores its potential as an adjunctive treatment in cancer care [9].

Hepatitis Treatment

Thymosin Alpha-1, has been studied for its potential to treat the viral infection like chronic hepatitis. India Clinical practice indicates that Thymosin Alpha-1 may play a role in boosting the immune response against hepatitis viruses, potentially aiding in the treatment of chronic hepatitis B and hepatitis C infections. By modulating the immune system and enhancing antiviral activity, Thymosin Alpha-1 shows promise as an immunomodulatory agent in the context of hepatitis management.

Buy Thymosin Alpha-1 Pen kits and pre-mixed refill cartridges supplied by PharmaLabGlobal India for research purposes.

Thymosin Alpha-1 FAQs

Do I need to reconstitute Thymosin Alpha-1?

When purchasing a peptide vial for clinical research you will need to use Bacteriostatic Water or Sterile Water to reconstitute the peptide before use. Peptide nasal sprays and refill cartridges designed for peptide pens have already undergone reconstitution for your convenience.

Does Thymosin Alpha-1 have side effects?

Thymosin Alpha-1 is generally well-tolerated and considered safe, however has still not been approved by the drug administration agency for human consumption. When researching any medication or therapy it is essential to monitor the potential adverse events and effects. Some reported side effects of Thymosin Alpha-1 may include redness or swelling at the injection site, mild flu-like symptoms, and occasional headaches. 

Could Thymosin Alpha-1 be a potential Immunotherapy agent?

Thymosin Alpha-1 has emerged as a potential immunotherapy agent due to its ability to modulate the immune system effectively. This synthetic peptide has shown promise in boosting immune responses, enhancing immune cell activities, and regulating immune functions. These properties make Thymosin Alpha-1 a compelling candidate for immunotherapy applications, particularly in conditions where immune system modulation is crucial, such as autoimmune disorders, viral infections, and certain types of cancer. Further research and clinical trials are necessary to fully explore and harness the therapeutic potential of Thymosin Alpha-1 in the realm of immunotherapy.

What is another name for Thymosin Alpha-1?

Thymosin Alpha-1 is also known by other names, including Thymalfasin and Zadaxin. These alternative names may be used interchangeably to refer to the same synthetic peptide with immune-modulating properties.

Buy Thymosin Alpha-1 & LL-37 (Cap-18) Peptide Combo

Combining Thymosin Alpha-1 and LL-37 Cap 18 peptides can offer synergistic benefits in immune modulation and antimicrobial defense. Thymosin Alpha-1 enhances T-cell function and immune responses, while LL-37 Cap 18 exhibits potent antimicrobial properties, capable of disrupting bacterial membranes.

By integrating these peptides, a dual-action approach emerges: Thymosin Alpha-1 boosts the immune system’s ability to identify and combat pathogens, while LL-37 Cap 18 directly targets and eliminates harmful microbes. This combination may lead to a more robust immune response against infections, potentially accelerating recovery and bolstering overall immune health through a coordinated action on both immune regulation and pathogen eradication.

Buy Thymosin Alpha-1 and LL-37 (Cap -18) Peptide Combo Pack here.

Scientific Research

[1] King R, Tuthill C. Immune Modulation with Thymosin Alpha 1 Treatment. Vitam Horm. 2016;102:151-78.

[2] Tuthill C, Rios I, McBeath R. Thymosin alpha 1: past clinical experience and future promise. Ann N Y Acad Sci. 2010 Apr;1194:130-5.

[3] Zhang C, Zhou J, Cai K, Zhang W, Liao C, Wang C. Gene cloning, expression and immune adjuvant properties of the recombinant fusion peptide Tα1-BLP on avian influenza inactivate virus vaccine. Microb Pathog. 2018 Jul;120:147-154.

[4] Pei F, Guan X, Wu J. Thymosin alpha 1 treatment for patients with sepsis. Expert Opin Biol Ther. 2018 Jul;18(sup1):71-76.

[5] Kharazmi-Khorassani J, Asoodeh A, Tanzadehpanah H. Antioxidant and angiotensin-converting enzyme (ACE) inhibitory activity of thymosin alpha-1 (Thα1) peptide. Bioorg Chem. 2019 Jun;87:743-752.

[6] Romani L, Oikonomou V, Moretti S, Iannitti RG, D’Adamo MC, Villella VR, et al. Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis. Nat Med. 2017 May;23(5):590-600. doi: 10.1038/nm.4305. Epub 2017 Apr 10. Erratum in: Nat Med. 2018 Sep;24(9):1481.

[7] Romani L, Bistoni F, Gaziano R, Bozza S, Montagnoli C, Perruccio K, Pitzurra L, Bellocchio S, Velardi A, Rasi G, Di Francesco P, Garaci E. Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling. Blood. 2004 Jun 1;103(11):4232-9.

[8] Romani L, Bistoni F, Montagnoli C, Gaziano R, Bozza S, Bonifazi P, Zelante T, Moretti S, Rasi G, Garaci E, Puccetti P. Thymosin alpha1: an endogenous regulator of inflammation, immunity, and tolerance. Ann N Y Acad Sci. 2007 Sep;1112:326-38. 

Further Reading:

Top Peptides for Improved Immunity

In the realm of immune support research, this blog delves into the efficacy of various peptides, highlighting Thymosin Alpha-1 as a standout player. This blog explores how Thymosin Alpha-1’s immunomodulatory properties can bolster the body’s defences, making it a potent contender for the future therapy in enhancing immune resilience and overall well-being.

Discover more about the future of immunity therapy.

How Peptides Can Help Manage Anxiety

In the blog we investigate how the spotlight falls on the remarkable potential of peptides, notably Thymosin Alpha-1, in addressing anxiety. Delving into the calming effects of Thymosin Alpha-1 on the immune system and stress response, this piece uncovers how this peptide offers a unique pathway towards alleviating anxiety and promoting emotional well-being.

Check out the full blog here.

Peptides for Mental Health: A Comprehensive Guide

Thymosin Alpha-1 emerges as a pivotal peptide in the realm of mental well-being. This guide explores how Thymosin Alpha-1’s immune-regulating properties extend to promoting mental health by potentially reducing inflammation and enhancing resilience to stressors. Discover how peptides, can offer a promising avenue for supporting mental wellness and cognitive function.

Read the guide here.

Why Buy Thymosin Alpha-1 from PharmaLabGlobal?

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